There is no biggest game in Spanish football, Real Madrid against Barcelona , and the pair will once again do battle in the Copa del Rey semi-final.

Both teams suffered disappointing results in their last domestic outings, dropping points, but they will be hoping to defeat their biggest rival to book a place in the final, as well as potentially landing a damaging blow to their opponent's title challenge.

Everyone knows the two teams have excellent qualities, Los Blancos showed them against Liverpool, whilst the Blaugrana have largely been excellent in Spain this term.

However, both are arriving into the Copa del Rey tie with fragile confidence after some poor results.

Real Madrid vs Barcelona predicted line-ups

Real Madrid have suffered a lot of injuries throughout the course of the campaign, but they will be without Ferland Mendy, David Alaba and Rodrygo Goes for the visit of Los Cules.

Barcelona will make the trip without Ousmane Dembele, Pedri, Robert Lewandowski and Ansu Fati who are all injured.

There is also a question mark over Raphinha's fitness as he is struggling with a knock.

Real Madrid's predicted XI (4-3-3): Courtois, Carvajal, Militao, Rudiger, Nacho, Kroos, Modric, Tchouameni, Valverde, Vinicius Jr, Benzema

Barcelona's predicted XI (4-3-3): Ter Stegen, Kounde, Araujo, Christensen, Balde, Busquets, Kessie, De Jong, Raphinha, Gavi, Torres

When does Real Madrid and Barcelona start?

The Copa del Rey semi-final first-leg will get underway at 21:00 CET on Thursday March 2, the local time in Madrid. For viewers in the UK that will be a 20:00 GMT kick-off time. In the United States this will equate to a 12:00 PT and 15:00 ET start time.

Where to watch Real Madrid and Barcelona

Viewers in the United Kingdom can watch liver coverage of the Clasico on BT Sport 1, whilst the BT Sport app will also offer a livestream of the match. Viewers in the United States will be able to watch on ESPN+.