Liverpool host Real Madrid at Anfield on Wednesday for the second leg of the Champions League quarter final tie between the two European heavyweights.

Los Blancos have a big advantage from their 3-1 win in Madrid, but the English giants are synonymous with epic European comebacks, meaning that the tie is far from a foregone conclusion.

Real Madrid enter the game in fine spirits after defeating rivals Barcelona on the weekend, while Liverpool regained some confidence with a narrow win over Aston Villa.

Both sides have central defensive problems, as the Reds continue to miss Virgil van Dijk and Joe Gomez, while Sergio Ramos and Raphael Varane are ruled out for Los Blancos.

When and when to watch Liverpool vs Real Madrid in the USA

The match between Liverpool and Real Madrid will take place at 21:00 CET (15:00 EST), and it will be available to watch on CBS Sports, as well as TUDN and Unimas, in the USA.

In addition, you can track the action as it happens here on MARCA.com/en/