The Manchester United striker has been in trouble since he missed training shortly after drinking in a nightclub in Belfast, in an incident caught and subsequently shared on social media.
Ahead of Thursday night's game against Wolves, Ferdinand revealed that plenty of people make mistakes, and it is up to Rashford to prove himself, during the Premier League game and the weeks that follow.
Rashford did not wait to make an impact at Molineux, curling in a goal inside five minutes of the start of the Premier League game at Wolves.
Speaking before the game, Ferdinand told TNT Sports: 'I think we don't know exactly what happened. The club have looked in it looks like a disciplinary action has been taken, so he's obviously stepped out of line somewhere.
Marcus Rashford scored Man United's opening goal against Wolves after being left out
TNT Sports' Rio Ferdinand called for a 'response' from Rashford before kick-off at Molineux
Rashford was penalised by the club for a disciplinary issue which meant he missed training
'But to me, it looks like he's missed training. And listen, if we're all being honest, we've done things where we stepped out a lot of times in our career. And fortunately for me, I was protected by a club that was in a good position, it was doing well it was confident. All eyes weren't on us for the wrong reasons.
'And sometimes you have to be aware of where your club are, and what your position is and what your role is within that. And you have to take the right steps.
'People are allowed to make mistakes. But in this situation, and again, you're not looking at someone like Marcus Rashford as being a young kid. He's one of the most experienced players here. He is Mr. Manchester United right now.
'He's propelled himself into that position for his performance prior to this, and you have to then act accordingly.
'And I think he's let his guard down in this situation. He seems to have been punished behind the scenes but I want to see a performance now and he's put that pressure on himself now. There needs to be a reaction and a good reaction now.'
Rashford's fifth-minute goal was his first involvement in a United squad since footage emerged on social media showing him entering a nightclub in Belfast on Thursday, before calling in sick and missing a training session at Carrington on Friday morning.
Rashford had been seen entering Belfast night club Thompsons Garage late last week
Rasmus Hojlund, middle, added Manchester United's second goal in the 22nd minute
His goal - his third in three league matches - was added to by Rasmus Hojlund in the 22nd minute, putting the visitors 2-0 up.
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